I have clots in my left leg, can the right leg become affected too?

I have Factor V Leiden and now have two permanent clots in my left leg. I was also recently diagnosed with post-thrombotic syndrome (PTS). My question is about venous insufficiency, as my legs are tired and weak. Even though the clots are just in the left leg, can the right become affected too?

Answers from doctors (7)


Palm Vein Center

Published on Oct 08, 2013

That depends. Venous insufficiency are mostly hereditary. PTS, however, covers a multitude of venous disorders, including venous insufficiency and is usually specific to the affected leg. To determine whether the other leg is affected, an ultrasound by a skilled phlebology sonographer is crucial. DON'T go to an imaging center to have this done, go to a reputable vein practice for accuracy.

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Answered by Palm Vein Center

That depends. Venous insufficiency are mostly hereditary. PTS, however, covers a multitude of venous disorders, including venous insufficiency and is usually specific to the affected leg. To determine whether the other leg is affected, an ultrasound by a skilled phlebology sonographer is crucial. DON'T go to an imaging center to have this done, go to a reputable vein practice for accuracy.

Published on Jul 11, 2012


The Sheen Vein Institute

Published on Sep 27, 2013

You are inherently at risk for blood clots due to your Factor V issues. It really does not matter whether it is your left or right leg or any other part of your body for that matter. Unfortunately, in the setting of vein disease, your blood tends to be more stagnant. Stagnant blood tends to clot. The fatigue in your legs are probably due to your vein disease. It is unlikely to be due to your history of blood clots, or even the PTS since that should only affect your left leg where the clots were. Your right should be fine. Based on what you are telling me, you should have your legs evaluated for vein issues, and you really need to wear compression stockings on your left leg if you are not already doing so. This will help control the progression of your PTS. Having your leg veins treated, especially if you have a lot of it, can actually make your legs feel better and help to decrease the pooling of blood in your legs. This can help decrease your blood clot risk even with Factor V issues.

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Answered by The Sheen Vein Institute

You are inherently at risk for blood clots due to your Factor V issues. It really does not matter whether it is your left or right leg or any other part of your body for that matter. Unfortunately, in the setting of vein disease, your blood tends to be more stagnant. Stagnant blood tends to clot. The fatigue in your legs are probably due to your vein disease. It is unlikely to be due to your history of blood clots, or even the PTS since that should only affect your left leg where the clots were. Your right should be fine. Based on what you are telling me, you should have your legs evaluated for vein issues, and you really need to wear compression stockings on your left leg if you are not already doing so. This will help control the progression of your PTS. Having your leg veins treated, especially if you have a lot of it, can actually make your legs feel better and help to decrease the pooling of blood in your legs. This can help decrease your blood clot risk even with Factor V issues.

Published on Jul 11, 2012


Arizona Vein Specialists

Published on Sep 12, 2013

Yes. Wear prescribed compression stockings and have your superficial venous insufficiency evaluated.

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Answered by Arizona Vein Specialists

Yes. Wear prescribed compression stockings and have your superficial venous insufficiency evaluated.

Published on Jul 11, 2012


Cosmetic Vein Centers of Texas

Published on Sep 10, 2013

Yes, the right leg can develop clots.

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Answered by Cosmetic Vein Centers of Texas

Yes, the right leg can develop clots.

Published on Jul 11, 2012


Vein Specialties of St. Louis

Published on Sep 10, 2013

Yes, you are at risk of clotting in the other leg. We would highly recommend that you wear at least 20-30 mmHg, higher if needed and a thigh length hose. Post thrombotic syndrome especially with clots higher in the leg can cause long term problems. You should be managed by a hematologist. Also a consultation with a lymphedema clinic for ongoing swelling management may be advisable.

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Answered by Vein Specialties of St. Louis

Yes, you are at risk of clotting in the other leg. We would highly recommend that you wear at least 20-30 mmHg, higher if needed and a thigh length hose. Post thrombotic syndrome especially with clots higher in the leg can cause long term problems. You should be managed by a hematologist. Also a consultation with a lymphedema clinic for ongoing swelling management may be advisable.

Published on Jul 11, 2012


General Vascular Surgery Group

Published on Sep 09, 2013

If the right leg develops clots, it could become affected. Discuss this matter with your MD, you might need long term anticoagulants.

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Answered by General Vascular Surgery Group

If the right leg develops clots, it could become affected. Discuss this matter with your MD, you might need long term anticoagulants.

Published on Jul 11, 2012


Vanish Vein and Laser Center

Published on Sep 09, 2013

Since you have an underlying propensity to form clots there will always be a potential to form new clots either in the same or opposite leg. However, many people with heterozygous Leiden V do well throughout their lifetime. You should be followed by a hematologist. It would be prudent for you to wear knee length support hose, exercise and stay trim. All of these things will help to minimize the effects of PPS.

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Answered by Vanish Vein and Laser Center

Since you have an underlying propensity to form clots there will always be a potential to form new clots either in the same or opposite leg. However, many people with heterozygous Leiden V do well throughout their lifetime. You should be followed by a hematologist. It would be prudent for you to wear knee length support hose, exercise and stay trim. All of these things will help to minimize the effects of PPS.

Published on Jul 11, 2012


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